1 Boreham Wood v AFC Wimbledon
2 Yeovil Town v AFC Bournemouth
3 Stoke City v Leyton Orient
4 Swansea City v Southampton
5 Chelsea v Chesterfield
6 Liverpool v Shrewsbury Town
7 Cardiff City v Preston North End
8 Coventry City v Derby County
9 Burnley v Huddersfield Town
10 West Bromwich Albion v Brighton & Hove Albion
11 Kidderminster Harriers v Reading
12 Leicester City v Watford
13 Mansfield Town v Middlesbrough
14 Hartlepool United v Blackpool
15 Hull City v Everton
16 Bristol City v Fulham
17 Tottenham Hotspur v Morecambe
18 Millwall v Crystal Palace
19 Port Vale v Brentford
20 Swindon Town v Manchester City
21 Wigan Athletic v Blackburn Rovers
22 Luton Town v Harrogate Town
23 Birmingham City v Plymouth Argyle
24 Manchester United v Aston Villa
25 Wolverhampton Wanderers v Sheffield United
26 Newcastle United v Cambridge United
27 Barnsley v Ipswich Town or Barrow
28 Peterborough United v Bristol Rovers
29 West Ham United v Leeds United
30 Queens Park Rangers v Rotherham United
31 Charlton Athletic v Norwich City
32 Nottingham Forest v Arsenal

The fixtures will take place from 7 to 10 January, 2022 with at least one tie typically chosen for television coverage on both the Friday and Monday.